ADAMTS13 in Bothrops lanceolatus snakebite envenoming: Crude venom-induced reduction of in vitro enzymatic activity and clinical correlation in snakebite patients
For the first time, our study provided evidence suggesting that ADAMTS13 activity is reduced in experimental B. lanceolatus venom exposure and patients with B. lanceolatus envenoming. Thanks to its role on the VWF regulation, it is suggested that reduced ADAMTS13 activity can increase the risk of thrombosis in B. lanceolatus envenoming by favoring the circulation of prothrombotic VWF multimers. Low ADAMTS13 activity was associated with increased length of stay in envenomed patients.
Authors
- Rémi Nevière (ORCID: https://orcid.org/0000-0002-7966-0110)
- Jonathan Florentin (ORCID: https://orcid.org/0000-0001-7481-4128)
- Pascal Fuseau
- Dabor Résière (ORCID: https://orcid.org/0000-0002-7273-2521)
- Hatem Kallel (ORCID: https://orcid.org/0000-0002-5663-0349)
- Fatima Radouani (ORCID: https://orcid.org/0009-0005-4168-5127)
- Prisca Jalta
- Caroline Rapon
- Olivier Pierre-Louis
Institutions
- University of French Guiana (GF)
- Centre Hospitalier Universitaire de Martinique (MQ)
- Université des Antilles (GP)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1371/journal.pntd.0013678
- Primary Topic
- Venomous Animal Envenomation and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00