Moderate–high efficacy disease-modifying therapies reduce relapse risk in late-onset multiple sclerosis
Moderate-high-efficacy DMTs reduced relapse risk in LOMS. Relapse activity was low. CDP was common and driven by PIRA. Although the CDP and RAW results did not reach statistical significance, the overall findings support the initial use of moderate-high-efficacy DMTs in LOMS.
Authors
- Bianca Weinstock-Guttman
- Murat Terzi (ORCID: https://orcid.org/0000-0002-3586-9115)
- Daniel Merlo (ORCID: https://orcid.org/0000-0001-8766-3453)
- Guy Laureys (ORCID: https://orcid.org/0000-0002-1708-4373)
- Nevin John (ORCID: https://orcid.org/0000-0002-9834-4498)
- Yi Chao Foong (ORCID: https://orcid.org/0000-0001-6447-078X)
- Radek Ampapa
- Tomáš Kalinčík (ORCID: https://orcid.org/0000-0003-3778-1376)
- Dana Horáková (ORCID: https://orcid.org/0000-0003-1915-0036)
- Alessandra Lugaresi (ORCID: https://orcid.org/0000-0003-2902-5589)
- Anneke van der Walt (ORCID: https://orcid.org/0000-0002-4278-7003)
- Masoud Etemadifar
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Julie Prévost (ORCID: https://orcid.org/0000-0002-8440-8577)
- Raed Alroughani (ORCID: https://orcid.org/0000-0001-5436-5804)
- Valentina Tomassini (ORCID: https://orcid.org/0000-0002-7368-6280)
- Cavit Boz (ORCID: https://orcid.org/0000-0003-0956-3304)
- Melissa Gresle (ORCID: https://orcid.org/0000-0003-0738-1136)
- Izanne Roos (ORCID: https://orcid.org/0000-0003-0371-3666)
- Pamela McCombe (ORCID: https://orcid.org/0000-0003-2704-8517)
- Samia Joseph Khoury (ORCID: https://orcid.org/0000-0003-3198-6063)
- Suzanne Hodgkinson (ORCID: https://orcid.org/0000-0002-9029-6663)
- Matteo Foschi (ORCID: https://orcid.org/0000-0002-0321-7155)
- Alexandre Prat (ORCID: https://orcid.org/0000-0001-6188-0580)
- Oliver Gerlach (ORCID: https://orcid.org/0000-0003-1565-1458)
- Eva Havrdová (ORCID: https://orcid.org/0000-0002-9543-4359)
- Vincent Van Pesch (ORCID: https://orcid.org/0000-0003-2885-9004)
- Claudio Marcello Solaro (ORCID: https://orcid.org/0000-0002-6713-4623)
- Andrea Surcinelli (ORCID: https://orcid.org/0000-0003-3779-0934)
- Chao Zhu (ORCID: https://orcid.org/0000-0003-3951-7501)
- Yolanda Blanco (ORCID: https://orcid.org/0000-0002-1834-0498)
- Vahid Shaygannejad
- Orla Gray (ORCID: https://orcid.org/0000-0002-7799-0116)
- Joana Guimarães (ORCID: https://orcid.org/0000-0001-6831-7352)
- Bassem Yamout
- Olga Skibina (ORCID: https://orcid.org/0009-0000-1542-5659)
- Helmut Butzkueven
- Marc Girard
- MSBase Study Group
- Katherine Buzzard
- Jeannette Lechner-Scott
Institutions
- Isfahan University of Medical Sciences (IR)
- University of Tasmania (AU)
- Cliniques Universitaires Saint-Luc (BE)
- The Royal Melbourne Hospital (AU)
- Box Hill Hospital (AU)
- Karadeniz Technical University (TR)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Dokuz Eylül University (TR)
- Charles University (CZ)
- Ondokuz Mayıs University (TR)
- Parks Victoria (AU)
- Craigavon Area Hospital (GB)
- Liverpool Hospital (AU)
- University Hospital of Wales (GB)
- Ghent University Hospital (BE)
- Multiple Sclerosis Society (GB)
- The Alfred Hospital (AU)
- University Hospital of Basel (CH)
- Royal Hobart Hospital (AU)
- Amiri Hospital (KW)
- Hospital de São João (PT)
- University of Isfahan (IR)
- University of Chieti-Pescara (IT)
- Gene Therapy Laboratory (FR)
- Hospital Jihlava (CZ)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- American University of Beirut Medical Center (LB)
- Hôpital Notre-Dame (CA)
- Monash Health (AU)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Universitair Ziekenhuis Brussel (BE)
- Zuyderland Medisch Centrum (NL)
- Centre Intégré de Santé et de Services Sociaux des Laurentides (CA)
- Jacobs Institute (US)
- Ospedale SS. Annunziata (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- General University Hospital in Prague (CZ)
- Alfred Health (AU)
- Menzies Institute for Medical Research
- Monash University (AU)
- Université de Montréal (CA)
- University of Newcastle Australia (AU)
- Cardiff University (GB)
- University of Genoa (IT)
- Hologic (Germany) (DE)
- University of Bologna (IT)
- American University of Beirut (LB)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1136/jnnp-2025-336513
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00