Genomic surveillance of <i>Streptococcus pneumoniae</i> in India: vaccine-driven serotype shifts, antimicrobial resistance, and emerging clonal lineages
India's pneumococcal population is undergoing vaccine-driven serotype replacement with concurrent expansion of MDR NVTs. Moreover, 31.4% discordance between phenotypic and WGS serotyping indicates that older phenotypic methods likely overestimated PCV coverage by ∼10%-12%, underscoring the need for genomics-first surveillance, incorporation of WGS into national monitoring, and evaluation of higher-valency or protein-based vaccines to ensure long-term disease control.
Authors
- James John (ORCID: https://orcid.org/0000-0003-3343-8677)
- Sangeetha Gopalakrishnan
- Premkumar Jayapal
Institutions
- Central Leprosy Teaching & Research Institute (IN)
- Sathyabama Institute of Science and Technology (IN)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1093/jambio/lxaf268
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00