Photocatalytic synthesis of CF3-containing <i>β</i> -amino alcohols via covalent metal–organic frameworks

The construction of CF₃-containing β-amino alcohols represents a promising approach for drug discovery due to their enhanced metabolic stability and tunable pharmacological properties. However, the development of non-noble metal heterogeneous photocatalysts for the efficient one-step synthesis of trifluoromethyl (CF₃)-containing β-amino alcohol motifs under mild conditions poses significant challenges. In this work, we successfully synthesized two photoactive covalent metal-organic frameworks capable of photocatalysing the one-step conversion of allylamines into CF₃-containing β-amino alcohols via trifluoromethylation and photooxidation. Notably, the catalytic reaction can be performed under continuous-flow conditions, reducing the reaction time from 12 h to 50 min while achieving a product yield of 6.2 g of CF₃-containing β-amino alcohol. Additionally, under a CO₂ atmosphere, CF₃-containing oxazolidinones can be efficiently obtained through the oxytrifluoromethylation of alkenes. Both catalytic reactions demonstrate high yields under natural sunlight illumination, further highlighting the practicality and sustainability of this approach.