Choline chloride/glycerol/l-arginine (TNADES) as a new sustainable solvent catalyst reaction media in multicomponent synthesis of biological corestones of 2,3-dihydroquinazolin-4(1H)-ones, spiro-2-oxindoles and pyrazole-4-carbonitriles under mild con

Ternary natural deep eutectic solvent (TNADES) made of choline chloride, glycerol, and l -arginine was used as an efficient, new reusable solvent/catalyst media for (i) the synthesis of 2-substituted-2,3-dihydroquinazolin-4(1 H )-ones through eco-friendly one-pot three-component reaction involving isatoic anhydride, ammonium acetate, various aldehydes or ketones, (ii) synthesis of spirooxindoles consisting of different isatines, malononitrile, and various nucleophiles such as 1,3-dicarbonyl compounds/4 H coumarin/α-naphthol, and (iii) the synthesis of pyrazole-4-carbonitriles using the most common raw materials such as phenylhydrazine, malononitrile, or ethyl cyanoacetate and various aldehydes under similar conditions. This solvent/catalyst media is easily and atomic economically synthesized and characterized by FT-IR, TGA, DSC, CV, viscosity, density, refractive index, ionic conductivity, potential of hydrogen (pH), and optical activity. The advantages of this method are the use of recyclable natural and environmentally friendly DES as a dual solvent/catalyst mixture, good to excellent efficiency, and safe and clean operation. • Sustainable solvent/catalyst made of choline chloride, glycerol, and l -arginine. • Dihydroquinazolin-4-ones, Spiro oxindoles, pyrazole-4-carbonitriles green synthesis. • Viable recyclable ternary deep eutectic solvent in biological corestones synthesis. • Capability of the sustainable solvent/catalyst media in multicomponent reactions.