Reconstructing the Origin and Demographic Expansion of the TP53 p.R337H Founder Variant in Brazil
This study highlights the value of integrating population genetics with historical data to elucidate the spread of medically relevant founder variants. Understanding the dissemination of TP53 p.R337H will enhance public health planning and genetic counseling strategies in Brazil. See related In the Spotlight, p. 187.
Authors
- João C. D. Muzzi (ORCID: https://orcid.org/0000-0002-6994-5577)
- José Andrés Yunes (ORCID: https://orcid.org/0000-0002-1316-3525)
- Gerard P. Zambetti (ORCID: https://orcid.org/0000-0002-0929-5007)
- Emília M. Pinto (ORCID: https://orcid.org/0000-0001-5567-000X)
- Bonald C. Figueiredo (ORCID: https://orcid.org/0000-0002-1051-2056)
- Raul Correa Ribeiro (ORCID: https://orcid.org/0000-0002-9956-5647)
Institutions
- St. Jude Children's Research Hospital (US)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Centro Infantil Boldrini (BR)
- Hospital Erasto Gaertner (BR)
- Instituto de Tecnologia do Paraná (BR)
Publication Details
- Journal
- Cancer Epidemiology Biomarkers & Prevention
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1158/1055-9965.epi-25-1148
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00