Real-World Effectiveness of Nirmatrelvir-Ritonavir in Preventing Coronavirus Disease 2019–Associated Hospitalization: A Population-Based Cohort Study in the Province of Québec, Canada
Nirmatrelvir-ritonavir reduces the risk of COVID-19-associated hospitalization among incompletely and completely vaccinated high-risk outpatients, as well as immunocompromised individuals, regardless of age and the delay since the last vaccination.
Authors
- Melanie R Tardif
- Jean‐Luc Kaboré (ORCID: https://orcid.org/0000-0001-7205-206X)
- Jeannot Dumaresq (ORCID: https://orcid.org/0000-0002-7660-7015)
- Mamadou Diop (ORCID: https://orcid.org/0000-0002-4208-0577)
- Hugo Chapdelaine (ORCID: https://orcid.org/0000-0001-6256-0271)
- Benoît Laffont
- Michel Cauchon (ORCID: https://orcid.org/0000-0003-3362-6977)
- Élie Haddad (ORCID: https://orcid.org/0000-0003-2446-6879)
- Marc Brosseau
- Mike Benigeri (ORCID: https://orcid.org/0000-0001-7393-067X)
- David Claveau (ORCID: https://orcid.org/0000-0003-3612-1122)
- Alexis F. Turgeon (ORCID: https://orcid.org/0000-0001-5675-8791)
- Me‐Linh Luong (ORCID: https://orcid.org/0000-0003-3756-892X)
Institutions
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Hôpital Maisonneuve-Rosemont (CA)
- The Quebec Population Health Research Network (CA)
- Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec (CA)
- Centre Intégré de Santé et Services Sociaux de Chaudière-Appalache (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Centre intégré de santé et de services sociaux de Chaudière-Appalaches (CA)
- Institut National d'Excellence en Santé et en Services Sociaux (CA)
- Montreal Clinical Research Institute (CA)
- Université Laval (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1093/cid/ciaf145
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00