HLA-B*58:01 and Risk of Allopurinol-Induced Severe Cutaneous Adverse Reactions in the US
These findings suggest that although HLA-B*58:01 was found to be associated with allopurinol-induced SCARs, generalizing findings from previous studies, the allele was absent in more than one-third of the patient cohort and is therefore an incomplete indicator of risk. Importantly, in the US allopurinol-induced SCAR cohort, HLA-A*34:02 was found to be a second independent genetic risk factor for allopurinol-induced SCARs. These findings underscore the need to conduct population-based studies that both reproduce known and uncover novel HLA associations to reduce harm through contributions to screening, risk stratification, and diagnosis.
Authors
- Kristina Williams
- Chelsea N. Campbell (ORCID: https://orcid.org/0000-0003-1630-6656)
- Michelle Goh (ORCID: https://orcid.org/0000-0001-8063-8482)
- Dana King (ORCID: https://orcid.org/0000-0002-3296-0407)
- Suman Pakala (ORCID: https://orcid.org/0000-0001-5156-0823)
- Aaron M. Drucker (ORCID: https://orcid.org/0000-0002-7388-9475)
- Elizabeth Ergen (ORCID: https://orcid.org/0000-0002-4748-5936)
- Robert G. Micheletti (ORCID: https://orcid.org/0000-0003-2517-7008)
- Matthew S. Krantz (ORCID: https://orcid.org/0000-0001-7589-9127)
- Benjamin Harris Kaffenberger (ORCID: https://orcid.org/0000-0001-8079-0011)
- Rama Gangula
- Michelle Martin‐Pozo (ORCID: https://orcid.org/0000-0002-1526-9569)
- Elizabeth Williams (ORCID: https://orcid.org/0000-0003-3255-4465)
- Rebecca Lee (ORCID: https://orcid.org/0000-0003-2540-2009)
- Aili Yu (ORCID: https://orcid.org/0000-0001-9652-8050)
- April O’Connor
- Elizabeth J. P. Phillips
- Kelby Mahan
- Amy Palubinksy
- Roni Dodiuk Gad
Institutions
- Johnson & Johnson (United States) (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- JAMA Dermatology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1001/jamadermatol.2025.4240
- Citations
- 2
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.79