Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)–2 Score
Through a methodologically robust development process, the SOFA-2 score offers updated definitions to describe organ dysfunction in adult patients requiring critical care and readily quantifiable criteria to grade the degree of dysfunction in individual organ systems. This score considers contemporaneous changes in patient management and outcomes.
Authors
- М. Yu. Кirov (ORCID: https://orcid.org/0000-0002-4375-3374)
- Jan J. De Waele (ORCID: https://orcid.org/0000-0003-1017-9748)
- Jean‐Louis Vincent (ORCID: https://orcid.org/0000-0001-6011-6951)
- Otávio T. Ranzani (ORCID: https://orcid.org/0000-0002-4677-6862)
- Pirkka T. Pekkarinen (ORCID: https://orcid.org/0000-0002-8203-3409)
- Rashan Haniffa
- Manu Shankar‐Hari (ORCID: https://orcid.org/0000-0002-5338-2538)
- Craig M. Coopersmith (ORCID: https://orcid.org/0000-0003-2400-3217)
- Dylan W. de Lange (ORCID: https://orcid.org/0000-0002-0191-7270)
- José Artur Paiva (ORCID: https://orcid.org/0000-0003-4323-0220)
- Márcio Soares (ORCID: https://orcid.org/0000-0003-2503-6088)
- Christian Jung (ORCID: https://orcid.org/0000-0001-8325-250X)
- Mervyn Singer (ORCID: https://orcid.org/0000-0002-1042-6350)
- Sheila Nainan Myatra (ORCID: https://orcid.org/0000-0001-6761-163X)
- Mohd Shahnaz Hasan (ORCID: https://orcid.org/0000-0002-7493-7416)
- Greg S. Martin (ORCID: https://orcid.org/0000-0002-9684-7593)
- Andrew J. Simpkin (ORCID: https://orcid.org/0000-0002-4975-444X)
- Charlotte Summers (ORCID: https://orcid.org/0000-0002-7269-2873)
- Wojciech Szczeklik (ORCID: https://orcid.org/0000-0002-1349-1123)
- Inès Lakbar (ORCID: https://orcid.org/0000-0003-0049-6248)
- Bram Rochwerg (ORCID: https://orcid.org/0000-0002-8293-7061)
- Lise Piquilloud (ORCID: https://orcid.org/0000-0002-4226-8772)
- Hayley B. Gershengorn (ORCID: https://orcid.org/0000-0002-7360-2489)
- Matti Reinikainen (ORCID: https://orcid.org/0000-0001-6878-3740)
- Cornelius Sendagire (ORCID: https://orcid.org/0000-0002-9039-7325)
- Suzana Margareth Lobo (ORCID: https://orcid.org/0000-0003-2726-2441)
- Dipayan Chaudhuri (ORCID: https://orcid.org/0000-0002-8305-1481)
- Philipp Metnitz
- Rui Paulo Moreno (ORCID: https://orcid.org/0000-0002-9795-8316)
- Vincent X. Liu (ORCID: https://orcid.org/0000-0001-6899-9998)
- M.D.P. Arias Lopez (ORCID: https://orcid.org/0000-0003-4881-4743)
- Jorge I. Salluh (ORCID: https://orcid.org/0000-0002-8164-1453)
- Joana Berger‐Estilita (ORCID: https://orcid.org/0000-0002-8695-4264)
- Bin Du (ORCID: https://orcid.org/0000-0002-4412-6778)
- Mariachiara Ippolito (ORCID: https://orcid.org/0000-0001-9851-6301)
- Annika Reintam Blaser (ORCID: https://orcid.org/0000-0003-1211-7372)
- Andrew Rhodes (ORCID: https://orcid.org/0000-0002-8737-574X)
- Fathima Paruk (ORCID: https://orcid.org/0000-0002-6549-0106)
- Edward James Schenck (ORCID: https://orcid.org/0000-0002-7950-5989)
- Nicole P. Juffermans (ORCID: https://orcid.org/0000-0002-3039-6574)
- Moses Siaw-Frimpong (ORCID: https://orcid.org/0009-0003-8128-4550)
- Anssi Pölkki (ORCID: https://orcid.org/0000-0001-8777-5287)
- Simon Oczkowski (ORCID: https://orcid.org/0000-0002-2874-8948)
- Fernando Godinho Zampieri (ORCID: https://orcid.org/0000-0001-9315-6386)
- Claúdia C. dos Santos (ORCID: https://orcid.org/0000-0002-6446-8791)
- John G. Laffey (ORCID: https://orcid.org/0000-0002-1246-9573)
- Tomoko Fujii (ORCID: https://orcid.org/0000-0003-3854-4081)
- Jeffrey Lipman
- David Pilcher
- Miguel Tavares (ORCID: https://orcid.org/0000-0002-6392-0379)
- Jukka Takala
- Nish Arulkumaran
- Ary Serpa Neto
- Elie Azoulay
- Chiara Robba
- Ricard Ferrer
- Jean-François Timsit
- Sharon Einav
- J. Wendon
- Ederlon Rezende
- Halle C. Prescott
- Steve Hollenberg
Institutions
- Université Claude Bernard Lyon 1 (FR)
- University of Bern (CH)
- Hebron University (PS)
- Jagiellonian University (PL)
- Grady Memorial Hospital (US)
- Université Libre de Bruxelles (BE)
- University of Helsinki (FI)
- Faculdade de Medicina de São José do Rio Preto (BR)
- University College London Hospitals NHS Foundation Trust (GB)
- Kaiser Permanente (US)
- Emory University (US)
- University of Alberta (CA)
- Inserm (FR)
- University of Beira Interior (PT)
- King's College - North Carolina (US)
- The University of Queensland (AU)
- University of Eastern Finland (FI)
- Universidade do Porto (PT)
- University of Toronto (CA)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Université de Montpellier (FR)
- Homi Bhabha National Institute (IN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Medical University of Graz (AT)
- Université Paris Cité (FR)
- Cornell University (US)
- University of Cambridge (GB)
- University of Michigan (US)
- Royal Brisbane and Women's Hospital (AU)
- Komfo Anokye Teaching Hospital (GH)
- Tata Memorial Hospital (IN)
- Hospital Israelita Albert Einstein (BR)
- Helsinki University Hospital (FI)
- Austin Hospital (AU)
- Hospital de Base (BR)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Ghent University Hospital (BE)
- Peking Union Medical College Hospital (CN)
- Hospital de Sant Pau (ES)
- Erasmus MC (NL)
- Saint Louis University Hospital (US)
- Bury College (GB)
- University Hospital Galway (IE)
- Steve Biko Hospital (ZA)
- Maccabi Healthcare Services (IL)
- Hospital de São João (PT)
- University Medical Center Utrecht (NL)
- University of Malaya (MY)
- Australian and New Zealand Intensive Care Society (AU)
- Kuopio University Hospital (FI)
- Presbyterian Hospital (US)
- Hospital de São José (PT)
- Assistance Publique – Hôpitaux de Paris (FR)
- Intensive Care Society (GB)
- Vall d'Hebron Institut de Recerca (ES)
- D’Or Institute for Research and Education (BR)
- Ecologie & Evolution (FR)
- Data Fusion International (Ireland) (IE)
- MRC Centre for Regenerative Medicine (GB)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Occupational Cancer Research Centre (CA)
- VA Center for Clinical Management Research (US)
- The Jikei University Hospital (JP)
- University of Miami Hospital (US)
- Luzerner Kantonsspital (CH)
- Kaiser Permanente Santa Clara Medical Center (US)
- Hôpital Saint-Louis (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Ospedale Policlinico San Martino (IT)
- Barcelona Institute for Global Health (ES)
- Hospital do Servidor Público Estadual (BR)
- Centre for Inflammation Research (GB)
- King's College Hospital (GB)
- Hospital de Base (BR)
- Institute of Biomedical Science (GB)
- Impact (CA)
- Hospital General de Niños Ricardo Gutierrez (AR)
- Northern State Medical University (RU)
- Unity Health Toronto
- Heinrich Heine University Düsseldorf (DE)
- University College London (GB)
- Monash University (AU)
- St. Joseph’s Healthcare Hamilton (CA)
- Université de Nîmes (FR)
- Makerere University (UG)
- Universidade Nova de Lisboa (PT)
- University of Genoa (IT)
- University of Palermo (IT)
- Erasmus University Rotterdam (NL)
- University of Lausanne (CH)
- McMaster University (CA)
- University of Edinburgh (GB)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.45040
- Citations
- 13
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 17.60
Funders
- Pfizer
- World Health Organization
- Gilead Sciences
- Kaiser Permanente
- Alexion Pharmaceuticals
- University of Miami
- Ministerio de Ciencia, Innovación y Universidades
- Fonds Wetenschappelijk Onderzoek
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Ministério da Saúde
- Vlaamse regering
- Grifols
- CytoSorbents Europe
- National Institutes of Health
- Canadian Institutes of Health Research
- Japan Society for the Promotion of Science
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación
- European Social Fund