Clinical, toxicity and long-term neurocognitive outcomes of first-line intensive chemotherapy in infant medulloblastoma: a single-center cohort study following AIEOP recommendations
Our retrospective study of infants MB treated with first-line intensive chemotherapy shows encouraging survival rates. Importantly, neurocognitive function was preserved over time, supporting radiation-sparing strategies, and toxicity was manageable in all cases.
Authors
- Giovanna Stefania Colafati (ORCID: https://orcid.org/0000-0002-1142-4904)
- Giada Del Baldo (ORCID: https://orcid.org/0000-0003-3540-4331)
- Isabella Giovannoni (ORCID: https://orcid.org/0000-0002-9980-6594)
- Angela Mastronuzzi (ORCID: https://orcid.org/0000-0002-4408-2373)
- Selene Cipri (ORCID: https://orcid.org/0000-0002-8730-0094)
- Sabrina Rossi (ORCID: https://orcid.org/0000-0002-1477-8855)
- Evelina Miele (ORCID: https://orcid.org/0000-0002-4747-1032)
- Andrea De Salvo (ORCID: https://orcid.org/0000-0002-8520-8008)
- Valentina Di Ruscio (ORCID: https://orcid.org/0000-0002-9581-2751)
- Antonella Cacchione (ORCID: https://orcid.org/0000-0003-4901-9952)
- Sabina Vennarini (ORCID: https://orcid.org/0000-0002-8712-8781)
- Andrea Carai (ORCID: https://orcid.org/0000-0002-5203-7855)
- Giulia Albino
- Claudia D’Orazio (ORCID: https://orcid.org/0000-0002-0264-8519)
- Annalisa Lo Sasso
- Ludovica Corvino
Institutions
- University of Udine (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Bambino Gesù Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1007/s11060-025-05301-9
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00