Integrated multi-omics reveals glycolytic gene signatures of lung adenocarcinoma brain metastasis and the impact of Rac2 lactylation on immunosuppressive microenvironment
The glycolytic pathway plays a critical role in the metabolic reprogramming of tumor cells during lung adenocarcinoma brain metastasis. Tumor glycolysis is closely associated with lung cancer progression, brain metastasis, and immune evasion. The Rac2 could be affected by lactylation, and then facilitate the formation of an immunosuppressive tumor microenvironment by induce the M2 polarization of macrophages.
Authors
- Daya Luo (ORCID: https://orcid.org/0000-0003-1227-2436)
- Jing Cai (ORCID: https://orcid.org/0000-0002-6792-4959)
- Yuxi Luo (ORCID: https://orcid.org/0000-0003-4963-8526)
- Hao Yu (ORCID: https://orcid.org/0000-0002-1892-7993)
- Anwen Liu (ORCID: https://orcid.org/0000-0001-5279-1068)
- Fujuan Zeng
- Zhimin Zeng (ORCID: https://orcid.org/0000-0003-0959-3044)
- Yali Yi
- Long Huang (ORCID: https://orcid.org/0000-0003-4925-5162)
- Wenjie Xu (ORCID: https://orcid.org/0000-0001-7326-948X)
- Le Xiong
Institutions
- Nanchang University (CN)
- Jiangxi Provincial Cancer Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s12967-025-07207-6
- Citations
- 6
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Wu Jieping Medical Foundation