The effects of N-acetylcysteine and adipose-derived stem cells on tendon healing in chronic rotator cuff tears: a rabbit model study
Adipose tissue-derived stem cells and N-acetylcysteine independently promote tendon healing, with adipose tissue-derived stem cells showing superior effects on collagen organization and fatty infiltration reduction. Combined treatment with adipose tissue-derived stem cells and N-acetylcysteine demonstrated synergistic effects, resulting in optimal tendon regeneration and strength. These findings support the potential of adipose tissue-derived stem cells and N-acetylcysteine as complementary therapies for chronic rotator cuff injuries. Further research is warranted to explore their mechanisms of action and clinical applications.
Authors
- Zeynep Burçin Gönen (ORCID: https://orcid.org/0000-0003-2725-9330)
- Burak Çakar (ORCID: https://orcid.org/0000-0001-6295-2566)
- Erdal Uzun (ORCID: https://orcid.org/0000-0002-5456-3699)
- Sebati Başer Canbaz (ORCID: https://orcid.org/0000-0002-9197-2942)
- İpek Alemdaroğlu-Gürbüz (ORCID: https://orcid.org/0000-0001-5556-6608)
- Mehmet Fatih Uzun (ORCID: https://orcid.org/0000-0003-2327-5536)
- Arzu Yay (ORCID: https://orcid.org/0000-0001-8532-3543)
- Mustafa Ermiş (ORCID: https://orcid.org/0000-0003-2267-1238)
- Anıl Aydın
- Muhammed Şehit Karmaz
Institutions
- Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi (TR)
- Sivas State Hospital (TR)
- Kayseri Eğitim ve Araştırma Hastanesi (TR)
- Kahramanmaraş Sütçü İmam University (TR)
- Erciyes University (TR)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s12891-025-09258-8
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Erciyes Üniversitesi