Empagliflozin-pretreated BMSC exosomes attenuate myocardial ischemia-reperfusion injury by enhancing atad3a/pink1-dependent mitophagy
Our findings demonstrated that EMPA enhanced exosome secretion from BMSCs. Both EMPA-EXO and EXO attenuated MIRI by upregulating ATAD3A, which promoted PINK1/PARKIN-dependent mitophagy. Notably, EMPA-EXO exhibitd superior therapeutic efficacy compared to EXO, suggesting a promising strategy for optimizing MSC-derived exosome therapy in ischemic heart disease.
Authors
- Chunxiang Zhang (ORCID: https://orcid.org/0000-0001-8303-6495)
- Haiqiong Yang (ORCID: https://orcid.org/0009-0000-9633-6964)
- Zaiyong Zheng (ORCID: https://orcid.org/0000-0003-4731-1829)
- Qiuting Li
- Yuling Jing
- Ying Cai (ORCID: https://orcid.org/0000-0002-6284-8416)
- Yu Yang (ORCID: https://orcid.org/0000-0002-4518-3299)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s13287-025-04715-6
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project