Evaluation of the Real-World Practice of Model-Informed Therapeutic Drug Monitoring and Its Association With Pharmacokinetic Target Attainment Rates: A Large-Scale, Single-Center Retrospective Study
The use of model-informed TDM, measured as the proportion of TDM consultations, varied across drugs and was generally associated with higher PK target attainment rates. Renal impairment, obesity, and advanced age require specific considerations to determine optimal dosing.
Authors
- Ki Young Huh (ORCID: https://orcid.org/0000-0002-1872-9954)
- Byungwook Kim (ORCID: https://orcid.org/0000-0003-4032-6112)
- Yoonjin Kim (ORCID: https://orcid.org/0009-0004-2141-2407)
- Kyung‐Sang Yu (ORCID: https://orcid.org/0000-0003-0921-7225)
- Sungyeun Bae (ORCID: https://orcid.org/0000-0002-6584-9158)
- SeungHwan Lee (ORCID: https://orcid.org/0000-0002-1713-9194)
- Jiyeon Park (ORCID: https://orcid.org/0000-0003-1267-0573)
- Jioh Kang
- Jisoo Song (ORCID: https://orcid.org/0000-0002-6522-1803)
Institutions
- E Ink (South Korea) (KR)
- Seoul National University Hospital (KR)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1097/ftd.0000000000001402
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00