Insights into spheroid formation: interaction of ovarian cancer cells with macrophage populations in the tumor microenvironment
Macrophages and their exosomes play a critical role in modulating the architecture and functional behavior of spheroids, reflecting two key aspects of OC progression: the formation of immune cell-enriched spheroids in ascitic fluid and tumor-immune interactions at peritoneal metastatic sites. This model provides a clinically relevant platform for preclinical testing of therapeutic strategies targeting peritoneal dissemination in OC.
Authors
- R. Steven Conlan (ORCID: https://orcid.org/0000-0002-2562-3461)
- Simone Pisano (ORCID: https://orcid.org/0000-0002-5412-1241)
- Zuleyma Yajaira Jiménez Huerta (ORCID: https://orcid.org/0000-0003-4647-4546)
- Deyarina González (ORCID: https://orcid.org/0000-0002-1838-6752)
- Bruna Corradetti (ORCID: https://orcid.org/0000-0002-0345-4847)
- Paul Rees (ORCID: https://orcid.org/0000-0002-7715-6914)
- Jing Xiao
Institutions
- Houston Methodist (US)
- Baylor College of Medicine (US)
- Swansea University (GB)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s12967-025-07162-2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Swansea University
- Houston Methodist Research Institute