Systematic validation of miR-503-5p abnormal expression in diabetic vascular complications: a meta-analysis and exploration of its targeted regulatory mechanism in retinopathy
MiR-503-5p was significantly upregulated in diabetic vascular complications, particularly in cell samples and major vascular complications. MiR-503-5p may serve as a diagnostic biomarker for diabetic retinopathy. The elevated levels of miR-503-5p in ARPE-19 cells under high glucose conditions were associated with increased inflammation, oxidative stress, and apoptosis, as well as decreased cell proliferation.
Authors
- Yong Zeng (ORCID: https://orcid.org/0000-0003-0119-2852)
- Kangli Deng (ORCID: https://orcid.org/0000-0003-0256-1322)
- Ping Shuai (ORCID: https://orcid.org/0000-0001-5857-0186)
- Xian Wang (ORCID: https://orcid.org/0000-0001-8656-4461)
- Mo Zhang (ORCID: https://orcid.org/0000-0002-5218-9007)
- Yongli Lan (ORCID: https://orcid.org/0009-0004-4492-5002)
Institutions
- University of Electronic Science and Technology of China (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s13098-025-01982-4
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00