Characterization of the unconventional meroterpenoid gene cluster from Stachybotrys sp. CPCC 401591 for phenylspirodrimanes biosynthesis
Genome discovery and gene deletion experiments unveiled a previously uncharacterized biosynthetic gene cluster psd involved in the biosynthesizing PSD derivatives in Stachybotrys sp. CPCC 401591. In addition, based on the gene cluster data and transcriptomic analyses, a hypothetical biosynthetic pathway of 1 was put forward.
Authors
- Bing Song (ORCID: https://orcid.org/0009-0001-0661-4754)
- Liyan Yu (ORCID: https://orcid.org/0000-0002-8861-9806)
- Wenni He
- Ling Bu (ORCID: https://orcid.org/0000-0001-6149-4540)
- Lu Wang (ORCID: https://orcid.org/0000-0002-7953-312X)
- Tao Zhang (ORCID: https://orcid.org/0000-0002-0715-1739)
- Hui Lv (ORCID: https://orcid.org/0009-0002-9713-6299)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s12934-025-02853-3
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Medical Research Council