Dietary quercetin supplementation alleviates claw lesions in dairy cows by modulating the PI3K/Akt and NF-κB signaling pathways
In conclusion, our findings indicate that dietary quercetin supplementation alleviates claw lesions and decreases the inflammatory response of lamellar tissues in dairy cows by modulating the PI3K/Akt and NF-κB signaling pathways. These results suggest that quercetin may serve as a natural anti-inflammatory candidate for the management of claw lesions in dairy cattle, offering new insights to improve hoof health and animal welfare in modern dairy pastures.
Authors
- Gonghe Li
- Chongya Zhai
- Xiaonan Yang (ORCID: https://orcid.org/0009-0002-8428-1681)
- Lei Lei (ORCID: https://orcid.org/0000-0002-5157-7606)
- Wenjun Wu (ORCID: https://orcid.org/0000-0003-0044-1917)
- Chunxia Ma
- Hao Peng (ORCID: https://orcid.org/0009-0006-6196-8543)
- Jiafeng Ding (ORCID: https://orcid.org/0009-0004-7884-821X)
- Shi Ming-xian
- Jingyi Lin (ORCID: https://orcid.org/0009-0003-3645-846X)
- Yimin Zheng
- Jing Mu
Institutions
- Guangxi University (CN)
- Guangxi Medicinal Botanical Garden (CN)
- Guangxi Veterinary Research Institute (CN)
- Guangxi Center for Disease Prevention and Control (CN)
- Nanning Normal University (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s12917-025-05089-w
- Citations
- 1
- Primary Topic
- Milk Quality and Mastitis in Dairy Cows
- Type
- article
- Field-Weighted Citation Impact
- 1.90
Funders
- National Key Research and Development Program of China
- Guangxi Key Research and Development Program