Spatio-temporal kinetics of patients’ CAR-T cells in blood and serous cavity effusion: real-world clinical insights
We characterized the spatial and temporal distribution of CAR-T cells and identified associations between CAR copy numbers and local inflammation, tumour invasion, and adverse events. These findings enhance our understanding of CAR-T cells diffusion, trafficking, and expansion, providing novel insights for clinical management and therapeutic optimization.
Authors
- Yi Xiao (ORCID: https://orcid.org/0000-0002-5124-8378)
- Yuekun Fang (ORCID: https://orcid.org/0009-0004-7282-8365)
- Liting Chen (ORCID: https://orcid.org/0000-0002-7786-1226)
- Man Zhang (ORCID: https://orcid.org/0000-0002-8977-2239)
- Xiaoying Zhang (ORCID: https://orcid.org/0000-0001-8057-0764)
- Caixia Chen (ORCID: https://orcid.org/0000-0003-2985-8441)
- Wanying Liu
Institutions
- Shenzhen University (CN)
- Wuhan No.1 Hospital (CN)
- Wuhan No.9 Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1007/s13402-025-01120-2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China