hPSC-derived sacral neural crest cells restore erectile function in pelvic ganglia injury
Our results demonstrate that hPSC-derived sacral NC cells represent a novel therapeutic strategy for neurogenic ED, restoring pelvic autonomic nerve structure and function through both neurogenic differentiation and sustained neurotrophic support.
Authors
- Yujie Zhou
- Yuxin Wu (ORCID: https://orcid.org/0000-0002-2657-8498)
- Wenwei Liu
- Wu‐Chul Song (ORCID: https://orcid.org/0000-0001-9678-1830)
- Xiaofeng Wang (ORCID: https://orcid.org/0000-0002-3180-8542)
- Yongxin Zhang (ORCID: https://orcid.org/0000-0001-7457-5905)
- Qiao Tang
- Ting Yang (ORCID: https://orcid.org/0000-0003-0174-8072)
- Tianxiang Lei (ORCID: https://orcid.org/0009-0006-4279-2503)
- Hufei Wang (ORCID: https://orcid.org/0009-0006-9816-2092)
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s13287-025-04734-3
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province