Efficacy of Praziquantel for Treatment of <i>Plasmodium falciparum</i> Infection in Asymptomatic Gabonese Adults: A Double-Blind Placebo-Controlled Randomized Trial
Findings demonstrate a statistically significant antimalarial activity of PZQ; however, the observed effect is only moderate compared to current first-line antimalarial treatments. Future research should investigate the synergistic potential of combining PZQ and antimalarial drugs in malaria and schistosomiasis control. Clinical Trials Registration.Pan African Clinical Trials Registry, PACTR202206584817951, 10 June 2022 (https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=22586).
Authors
- Michael Ramharter (ORCID: https://orcid.org/0000-0002-9259-1885)
- Rella Zoleko‐Manego (ORCID: https://orcid.org/0000-0001-7425-2794)
- Ghyslain Mombo‐Ngoma (ORCID: https://orcid.org/0000-0003-2658-8706)
- Michael Vögler (ORCID: https://orcid.org/0000-0001-9404-3340)
- Andrea Kreidenweiss (ORCID: https://orcid.org/0000-0002-5025-7221)
- Wilfrid Ndzebe Ndoumba (ORCID: https://orcid.org/0000-0002-8213-4912)
- Dearie Glory Okwu (ORCID: https://orcid.org/0000-0002-4025-2320)
- Peter G. Kremsner (ORCID: https://orcid.org/0000-0002-3926-4113)
- Johannes Mischlinger (ORCID: https://orcid.org/0000-0002-2012-6327)
- Florian Kurth (ORCID: https://orcid.org/0000-0002-3807-473X)
- Anna Bachmann (ORCID: https://orcid.org/0000-0001-8397-7308)
- Ayôla Akim Adégnika (ORCID: https://orcid.org/0000-0003-3197-5946)
- Jacob Werner
- Francisca Sarpong
- Klara Pechmann
- Cäcilie von Wedel
- Alex Hounmenou Zinsou
- Lidwine Badjina
Institutions
- Universität Hamburg (DE)
- Humboldt-Universität zu Berlin (DE)
- Universitätsklinikum Tübingen (DE)
- Centre de Recherche Médicales de Lambaréné (GA)
- University Medical Center Hamburg-Eppendorf (DE)
- German Center for Infection Research (DE)
- University of Tübingen (DE)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1093/infdis/jiaf544
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00