Early elevation of complement-related proteins in metabolic dysfunction-associated steatotic liver disease (MASLD) with normal liver enzymes
Our study provides novel evidence that the complement system is already activated in patients with MASLD-NLE, potentially offering new avenues for treating MASLD at an early stage.
Authors
- Xueqing Zhong
- Junping Shi (ORCID: https://orcid.org/0000-0001-9434-897X)
- Weijie Wu (ORCID: https://orcid.org/0000-0002-4894-5981)
- Weishi Zhang (ORCID: https://orcid.org/0000-0003-0519-8397)
- Binbin Zhang (ORCID: https://orcid.org/0000-0002-4820-4702)
- Jie Li (ORCID: https://orcid.org/0000-0003-4643-2813)
- Wenjun Yang
- Li Shao (ORCID: https://orcid.org/0000-0002-3413-7537)
- Zhe Lyu (ORCID: https://orcid.org/0009-0004-5376-9793)
- Jing Liu (ORCID: https://orcid.org/0000-0001-5557-0084)
- Jinlong Fu
Institutions
- Zhejiang Chinese Medical University (CN)
- Hangzhou Normal University (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Affiliated Hospital of Hangzhou Normal University (CN)
- Nanjing Drum Tower Hospital (CN)
- Zhejiang Academy of Medical Sciences (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s12876-025-04361-5
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Hangzhou Normal University
- National Science and Technology Major Project
- Natural Science Foundation of Zhejiang Province