Gut microbiota-derived short-chain fatty acids promote follicular maturation via gWAT-ovary axis in mammals
Collectively, gut microbiota-derived SCFAs promote follicular maturation and increase litter size in sows by stimulating leptin secretion from peri-ovarian gWAT, thus providing novel insights into enhancing reproductive outcomes in mammals. Video Abstract.
Authors
- Wenxia Qin (ORCID: https://orcid.org/0000-0002-1782-7157)
- Juncheng Huang
- Xianghua Yan (ORCID: https://orcid.org/0000-0003-2238-6218)
- Z. Yan (ORCID: https://orcid.org/0000-0002-5033-088X)
- Libao Ma (ORCID: https://orcid.org/0000-0001-6806-6899)
- Yimei Tang (ORCID: https://orcid.org/0000-0002-6720-1005)
- Yuwen Chen (ORCID: https://orcid.org/0000-0003-3025-7096)
- Shuyi Zhou (ORCID: https://orcid.org/0009-0004-5510-7806)
- Baoyang Xu
Institutions
- Zhejiang A & F University (CN)
- Huazhong Agricultural University (CN)
- Ministry of Agriculture (ID)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s40168-025-02174-y
- Citations
- 5
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Natural Science Foundation of Zhejiang Province