Metabolism, pharmacokinetics, and bioavailability of cannabigerol in horses following intravenous and oral administration with micellar and oil formulations
This study shows the first evaluation of the <i>in vivo</i> metabolism and pharmacokinetics of CBG in horses after IV and oral administration. The findings highlight extensive metabolite formation with significant glucuronidation, a large distribution volume, and high clearance. While both oral formulations produced similar systemic exposure, the faster absorption with the micellar formulation may inform clinical decisions depending on therapeutic goals. These data support the potential use of CBG in horses and offer a foundation for further studies in equine medicine.
Authors
- Aritz Saitua (ORCID: https://orcid.org/0000-0002-6355-4815)
- Feliciano Priego‐Capote (ORCID: https://orcid.org/0000-0003-0697-719X)
- Carlos Ferreiro‐Vera (ORCID: https://orcid.org/0000-0002-1215-0626)
- E. Díez de Castro (ORCID: https://orcid.org/0000-0003-1553-1683)
- Carlos A. Ledesma‐Escobar (ORCID: https://orcid.org/0000-0002-4658-8212)
- Antonia Sánchez de Medina (ORCID: https://orcid.org/0000-0002-6466-1882)
- Raquel Miraz
- Juan Manuel Serrano (ORCID: https://orcid.org/0000-0001-5817-5514)
- Verónica Sánchez de Medina
Institutions
- Servicio Diabetología Hospital Córdoba (AR)
- University of Córdoba (ES)
- Cordoba University (US)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fvets.2025.1688214
- Primary Topic
- Pharmacological Effects and Assays
- Type
- article
- Field-Weighted Citation Impact
- 0.00