The distinct characteristics of the endophytic microbiome and metabolome within the root system result in varying abilities of watermelon resistance against Fusarium wilt

This study systematically reveals, for the first time, the synergistic defense mechanisms between root endophytic microbiome and metabolome during Fusarium wilt resistance formation in watermelon. Significantly, we have identified potential functional microorganisms, key metabolites, and critical pathways that actively contribute to these defense mechanisms. However, the specific functions of these potential antagonistic microorganisms and metabolites still need further validation. These findings provide a novel perspective for crop disease resistance research, transcending the limitations of traditional single-factor analytical paradigms, while establishing a methodological foundation for developing multi-omics integrated approaches in crop disease resistance regulation strategies.