Therapeutic effects of Bushen Chushi formula on knee osteoarthritis via modulation of MAPK/SLC7A11/GPX4 signaling in rats
BSCSF attenuated KOA progression in rats by inhibiting ferroptosis through the MAPK/SLC7A11/GPX4 signaling axis and suppressing inflammatory responses. The observed preservation of cartilage structure and enhancement of subchondral bone quality highlight its therapeutic potential in the management of KOA.
Authors
- Ming-Jiang He
- Y. Chen (ORCID: https://orcid.org/0009-0005-9544-5700)
- Hongmei Zhang (ORCID: https://orcid.org/0000-0002-3991-3750)
- Yuanyuan Li (ORCID: https://orcid.org/0000-0003-4227-8628)
- Xinyue Wang (ORCID: https://orcid.org/0000-0001-6990-783X)
- Shaomin Liu (ORCID: https://orcid.org/0000-0001-5019-5182)
- Hai Tang
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Hereditas
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s41065-025-00587-1
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04