The Prognostic and Predictive Impact of ctDNA Levels in Patients with Advanced Breast Cancer Enrolled on the plasmaMATCH Trial
Baseline low ctDNA levels predict response to targeted therapy, potentially suggesting shared mechanisms between high ctDNA release and resistance to therapy. Both baseline ctDNA levels and on-treatment dynamics are a promising surrogate endpoint for drug development, with clearance of ctDNA being a robust cross-therapy surrogate for outcomes.
Authors
- Javier Pascual (ORCID: https://orcid.org/0000-0003-3874-2782)
- Judith M. Bliss (ORCID: https://orcid.org/0000-0001-7957-7424)
- Alistair Ring (ORCID: https://orcid.org/0000-0003-1230-2973)
- Isaac García-Murillas (ORCID: https://orcid.org/0000-0001-8183-7969)
- Belinda Kingston (ORCID: https://orcid.org/0000-0002-4921-4638)
- Miguel Gil‐Gil (ORCID: https://orcid.org/0000-0003-1380-2718)
- Iain R. Macpherson (ORCID: https://orcid.org/0000-0003-4295-8885)
- Alex Pearson (ORCID: https://orcid.org/0000-0002-5854-193X)
- Ángel Guerrero‐Zotano (ORCID: https://orcid.org/0000-0003-0318-9120)
- Rebecca Roylance (ORCID: https://orcid.org/0000-0003-1453-6343)
- Rosalind Cutts (ORCID: https://orcid.org/0000-0002-8297-9341)
- Sarah Hrebien
- Lucy Kilburn (ORCID: https://orcid.org/0000-0002-1987-7545)
- Nicholas C. Turner (ORCID: https://orcid.org/0000-0001-8937-0873)
- Laura Moretti (ORCID: https://orcid.org/0000-0003-0488-0140)
- Andrew Wardley (ORCID: https://orcid.org/0000-0002-9639-0888)
- Richard D. Baird (ORCID: https://orcid.org/0000-0001-7071-6483)
- Iseult Browne (ORCID: https://orcid.org/0009-0005-7193-987X)
- Miguel Martín (ORCID: https://orcid.org/0000-0001-9237-3231)
Institutions
- Royal Marsden NHS Foundation Trust (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Institute of Cancer Research (GB)
- Breast Cancer Now (GB)
- Cancer Research UK (GB)
- Hospital General Universitario Gregorio Marañón (ES)
- Cancer Research UK Cambridge Center (GB)
- Fundación Instituto Valenciano de Oncología (ES)
- Institut Català d'Oncologia (ES)
- Royal Marsden Hospital (GB)
- The Christie NHS Foundation Trust (GB)
- UCL Biomedical Research Centre (GB)
- Cancer Services (US)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- GEICAM – Spanish Breast Cancer Group (ES)
- University College London (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-0651
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00