Population Pharmacokinetics Analysis of Infliximab in up to 10-Year-Old Patients with Paediatric Inflammatory Bowel Disease: Label-Recommended Dose Fails to Achieve Therapeutic Target Concentration
Paediatric patients ≤ 10 years, demonstrated a higher IFX CL than paediatric patients > 10 to < 17 years and adults, with albumin and CRP explaining the variability of CL. The differences obtained across the IFX assays did not affect overall drug exposure. To maintain trough concentrations above 5 mg/L in paediatric patients ≤ 10 years, a dosing interval of 4 weeks is required.
Authors
- Qiaolin Zhao (ORCID: https://orcid.org/0009-0008-5800-0966)
- Amit Assa (ORCID: https://orcid.org/0000-0002-2787-4096)
- Tim Preijers (ORCID: https://orcid.org/0000-0001-6953-0358)
- Séamus Hussey (ORCID: https://orcid.org/0000-0002-9362-0465)
- Kaija‐Leena Kolho (ORCID: https://orcid.org/0000-0001-9170-8415)
- Tim G. J. de Meij (ORCID: https://orcid.org/0000-0002-7556-5896)
- Lorenzo Norsa (ORCID: https://orcid.org/0000-0003-3322-2921)
- Brenda C. M. de Winter (ORCID: https://orcid.org/0000-0002-4452-8443)
- Christine Martinez‐Vinson (ORCID: https://orcid.org/0000-0002-3010-6442)
- S Vuijk (ORCID: https://orcid.org/0000-0002-2710-7241)
- Lissy de Ridder (ORCID: https://orcid.org/0000-0002-6035-1182)
- Raffi Lev‐Tzion (ORCID: https://orcid.org/0000-0001-5193-9577)
- Eytan Wine (ORCID: https://orcid.org/0000-0002-3458-4142)
- Shlomi Cohen (ORCID: https://orcid.org/0000-0002-6190-3217)
- Dror S. Shouval (ORCID: https://orcid.org/0000-0001-5980-2954)
- M Jongsma
- Hien Q. Huynh (ORCID: https://orcid.org/0000-0002-7295-7595)
- Victorien M. Wolters
Institutions
- University of Helsinki (FI)
- University of Alberta (CA)
- Tel Aviv University (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Kaplan Medical Center (IL)
- Helsinki University Hospital (FI)
- Hospital for Sick Children (CA)
- Erasmus MC (NL)
- Shaare Zedek Medical Center (IL)
- Children's Health Ireland at Crumlin (IE)
- Emma Kinderziekenhuis (NL)
- National Children’s Research Centre (IE)
- Hôpital Robert-Debré (FR)
- Ospedale dei Bambini Vittore Buzzi (IT)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Amsterdam University Medical Centers (NL)
- Wilhelmina Children's Hospital (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1007/s40262-025-01565-6
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00