Recent intake of direct oral anticoagulants and acute ischemic stroke: real world data from a comprehensive stroke center
A considerable proportion of AIS patients with recent DOAC intake exhibited minimal or no anticoagulant activity at presentation. Those with the lowest levels also showed highest stroke severity. IVT was safe across all DOAC level groups, with low and comparable sICH rates. These findings support the rationale for a randomized trial evaluating IVT without prior DOAC level testing.
Authors
- Christoph Kleinschnitz (ORCID: https://orcid.org/0000-0002-1650-8875)
- Jordi Kühne Escolà (ORCID: https://orcid.org/0000-0002-8742-0694)
- Benedikt Frank (ORCID: https://orcid.org/0000-0001-8837-9489)
- Cornelius Deuschl (ORCID: https://orcid.org/0000-0001-9262-7289)
- Philipp Dammann (ORCID: https://orcid.org/0000-0003-3618-5150)
- Martin Köhrmann (ORCID: https://orcid.org/0000-0002-0701-9535)
- Michael Forsting (ORCID: https://orcid.org/0000-0002-5584-9824)
- Bastian Brune (ORCID: https://orcid.org/0000-0002-8525-7379)
- Doreen Pommeranz
- Yan Li (ORCID: https://orcid.org/0000-0002-3906-9481)
- Clemens Kill
- Nicole Lehr
Institutions
- Essen University Hospital (DE)
Publication Details
- Journal
- Neurological Research and Practice
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s42466-025-00438-4
- Citations
- 6
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 8.33