Hyperresponsiveness to inflammatory stimulation in human neuronal-like cells from patients with inflammation-associated depression
These findings suggest a hyperresponsive phenotype to inflammatory stimulation <i>in vitro</i> in early neurons from patients with depression and elevated peripheral inflammation. Our results may provide novel insights into how inflammation could influence neurodevelopmental processes relevant to depression and may serve as a model for further investigations regarding targeted interventions.
Authors
- Carmen Schiweck (ORCID: https://orcid.org/0000-0003-4215-0448)
- Florian Freudenberg (ORCID: https://orcid.org/0000-0003-1438-3850)
- Susanne Schillo
- T. Tsengenbayar
- Sharmili Edwin Thanarajah (ORCID: https://orcid.org/0000-0003-3608-1474)
- A.Y. Yotova (ORCID: https://orcid.org/0000-0002-4792-8696)
- Andreas Reif (ORCID: https://orcid.org/0000-0002-0992-634X)
- Mareike Aichholzer (ORCID: https://orcid.org/0000-0002-1291-3304)
Institutions
- Goethe University Frankfurt (DE)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- University Hospital Frankfurt (DE)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fpsyt.2025.1576880
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft