Diverse-Ancestry GWAS of Age-Related Macular Degeneration on 16,108 Examined Cases and 18,038 Controls
Our results indicate that the genetic underpinning of adAMD is mostly shared between ancestries. We also identify the CFH variant as being less relevant in specific ancestries, indicating a difference in pathogenic burden between ancestries. We increased the available genomic data for AMD over 300-fold with the IAMDGC 2.0 imputation, making it a valuable resource for further AMD genetic analysis.
Authors
- Xiaofeng Zhu (ORCID: https://orcid.org/0000-0003-0037-411X)
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- Michelle Grunin (ORCID: https://orcid.org/0000-0002-3155-2858)
- Susan H. Blanton (ORCID: https://orcid.org/0000-0002-5433-3439)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Nicholas R. Wheeler (ORCID: https://orcid.org/0000-0003-2248-8919)
- Margaret Ann Pericak‐Vance (ORCID: https://orcid.org/0000-0001-7283-8804)
- Yeunjoo E. Song (ORCID: https://orcid.org/0000-0002-7452-3731)
- Iris M. Heid (ORCID: https://orcid.org/0000-0002-4122-5308)
- Janina M. Herold (ORCID: https://orcid.org/0000-0002-2208-9742)
- Mathias Gorski (ORCID: https://orcid.org/0000-0002-9103-5860)
- Bruno Frøhlich (ORCID: https://orcid.org/0000-0003-4444-5733)
- Merle Behr
Institutions
- OTH Regensburg (DE)
- Hebrew University of Jerusalem (IL)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
- University of Regensburg (DE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1167/iovs.66.13.51
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- BrightFocus Foundation
- National Institutes of Health