Whole-Body [18F]FDG-PET/CT Imaging of Healthy Controls: Test/Retest Data for Systemic, Multi-Organ Analysis
Positron Emission Tomography (PET) with 2-deoxy-2-[<sup>18</sup>F]fluoro-D-glucose (FDG) and Computed Tomography (CT) are key tools in oncology diagnostics. However, most PET studies focus on tumour detection. We propose that a holistic assessment of the macroenvironment using FDG-PET could enhance our understanding of systemic treatment interactions and improve patient care. To achieve this, we aim to develop a normative database for FDG-PET based on healthy controls, providing a reference for identifying voxel-level metabolic aberrations in cancer patients. This approach may uncover treatment-related changes beyond cancer diagnostics. 48 healthy controls who underwent dynamic test-retest whole-body PET/CT imaging post [<sup>18</sup>F]FDG injection were included in this cohort. Static PET images (57-62 min post-injection) were reconstructed using CT-based attenuation and scatter correction, with iterative reconstruction incorporating resolution recovery and time-of-flight data. Standardized uptake values (SUVs), tissue densities (HU), and volumes for 135 organs were calculated using in-house segmentation software. The dataset, including anonymized PET/CT images and CT-derived segmentations in NIfTI format, supports the creation of a normative FDG-PET database and enables multi-organ analyses using PET/CT imaging.
Authors
- Georgios Karanikas (ORCID: https://orcid.org/0000-0002-0990-8627)
- Josef Yu (ORCID: https://orcid.org/0000-0003-1426-1538)
- Barbara Katharina Geist (ORCID: https://orcid.org/0000-0003-0098-0048)
- Lalith Kumar Shiyam Sundar (ORCID: https://orcid.org/0000-0003-3004-7937)
- Sebastian Gutschmayer (ORCID: https://orcid.org/0000-0002-7908-845X)
- Zacharias Chalampalakis (ORCID: https://orcid.org/0000-0003-3390-6979)
- Marcus Hacker (ORCID: https://orcid.org/0000-0002-4222-4083)
- Harald Ibeschitz
- Manuel Melo Pires (ORCID: https://orcid.org/0000-0002-0046-6455)
- Ivo Rausch (ORCID: https://orcid.org/0000-0002-4007-1669)
- Bettina Reiterits
- Daria Ferrara (ORCID: https://orcid.org/0000-0002-8711-8081)
- Thomas Beyer (ORCID: https://orcid.org/0000-0002-8308-3918)
- Öykü Özer (ORCID: https://orcid.org/0009-0009-0770-4354)
- Lukas Nics
- Werner Langsteger
- Dina Muin (ORCID: https://orcid.org/0009-0003-6243-3370)
Institutions
- LMU Klinikum (DE)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Scientific Data
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1038/s41597-025-05997-4
- Citations
- 2
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- King's College London
- European Commission
- Agence Nationale de la Recherche
- Austrian Science Fund
- Universität Wien
- Medizinische Universität Wien
- Siemens Healthineers