Electrolyte imbalance – a hidden factor in the outcomes of patients with out-of-hospital cardiac arrest

Introduction: Out-of-hospital cardiac arrest (OHCA) is commonly associated with metabolic and electrolyte disturbances, including acidosis, glucose dysregulation, and changes in potassium, calcium, magnesium, and lactate levels 1 .Persistent abnormalities after return of spontaneous circulation (ROSC) are frequently linked with adverse outcomes.The aim of this study was to evaluate the prevalence of electrolyte imbalance and its association with survival in OHCA patients. Results:We retrospectively analyzed 38 patients with OHCA, 78% male, most frequently aged 70-79 years.The most common initial rhythm was ventricular fibrillation (79%).Potassium levels were normal in 53% of patients, hypokalemia was observed in 36%, and hyperkalemia in 7.9%.Regarding fluid therapy, 500 ml of normal saline was administered in 28.9% of cases, while the remainder received various combined infusions.Statistical analysis showed a significant difference in potassium levels between survivors and non-survivors (p=0.018).No statistically significant differences were observed for sodium, chloride, bicarbonates, or lactates. Conclusion:These findings emphasize the prognostic importance of potassium status in OHCA.Early recognition and correction of hyperkalemia, hypokalemia, or severe acidosis are crucial for resuscitation outcomes and survival, given the central role of electrolytes in cardiac function and conduction.Beyond clinical management, strengthening public education and first aid training remains essential, since a single trained bystander can determine survival.Clinical guidelines should therefore integrate both medical and preventive perspectives.

Authors

Publication Details

Journal
Cardiologia Croatica
Published
2025-10-29
DOI
https://doi.org/10.15836/ccar2025.285
Primary Topic
Potassium and Related Disorders
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Electrolyte imbalance – a hidden factor in the outcomes of patients with out-of-hospital cardiac arrest

Ivica Benko, Biljana Hržić, Martina Vidak, Valentina Miler
Cardiologia Croatica
Potassium and Related Disorders
article

Electrolyte imbalance – a hidden factor in the outcomes of patients with out-of-hospital cardiac arrest

Ivica Benko, Biljana Hržić, Martina Vidak, Valentina Miler
article en

Abstract

Introduction: Out-of-hospital cardiac arrest (OHCA) is commonly associated with metabolic and electrolyte disturbances, including acidosis, glucose dysregulation, and changes in potassium, calcium, magnesium, and lactate levels 1 .Persistent abnormalities after return of spontaneous circulation (ROSC) are frequently linked with adverse outcomes.The aim of this study was to evaluate the prevalence of electrolyte imbalance and its association with survival in OHCA patients. Results:We retrospectively analyzed 38 patients with OHCA, 78% male, most frequently aged 70-79 years.The most common initial rhythm was ventricular fibrillation (79%).Potassium levels were normal in 53% of patients, hypokalemia was observed in 36%, and hyperkalemia in 7.9%.Regarding fluid therapy, 500 ml of normal saline was administered in 28.9% of cases, while the remainder received various combined infusions.Statistical analysis showed a significant difference in potassium levels between survivors and non-survivors (p=0.018).No statistically significant differences were observed for sodium, chloride, bicarbonates, or lactates. Conclusion:These findings emphasize the prognostic importance of potassium status in OHCA.Early recognition and correction of hyperkalemia, hypokalemia, or severe acidosis are crucial for resuscitation outcomes and survival, given the central role of electrolytes in cardiac function and conduction.Beyond clinical management, strengthening public education and first aid training remains essential, since a single trained bystander can determine survival.Clinical guidelines should therefore integrate both medical and preventive perspectives.

Cardiologia CroaticaVol. 20(11-12)
Openalex Percentile: Top 55%
Potassium and Related Disorders
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Electrolyte imbalance – a hidden factor in the outcomes of patients with out-of-hospital cardiac arrest — Ivica Benko, Biljana Hržić, et al. · Cardiologia Croatica (2025) | TGRS Research Map | TGRS