Lung injury promoted by strong inspiratory efforts and breath stacking: impact of ventilation mode
Breath stacking under strong inspiratory drive can promote lung injury through distinct mechanisms depending on ventilation mode. VCV was associated with the risk of overdistension, whereas PCV involved vigorous inspiratory effort and potential atelectrauma. Double triggering should be recognized as a clinical warning sign, prompting careful assessment of respiratory drive, inspiratory effort, and ventilator settings.
Authors
- Naofumi Bunya (ORCID: https://orcid.org/0000-0003-3605-402X)
- Shigeki Fujitani (ORCID: https://orcid.org/0000-0001-6327-682X)
- Junki Koike (ORCID: https://orcid.org/0000-0001-9026-244X)
- Taku Miyasho (ORCID: https://orcid.org/0000-0001-7831-5158)
- Hidenori Takeshima (ORCID: https://orcid.org/0000-0002-2557-8533)
- Yasuhiro Norisue (ORCID: https://orcid.org/0000-0002-8748-5404)
- Miyako Kyogoku (ORCID: https://orcid.org/0000-0002-0223-6901)
- Muneyuki Takeuchi (ORCID: https://orcid.org/0000-0001-9117-3596)
- Takaharu ITAMI (ORCID: https://orcid.org/0000-0002-4692-2495)
- Francesco Mojoli (ORCID: https://orcid.org/0000-0002-6031-6336)
- Ryuichi Nakayama (ORCID: https://orcid.org/0000-0002-3272-7680)
- Sunao Usami
- Chihiro Sugita (ORCID: https://orcid.org/0000-0001-9514-6798)
- Ayu Takemoto
- Yukie Ito
- Taku Hirokawa
- Atsushi Kawamura
- Jun Kataoka (ORCID: https://orcid.org/0000-0002-2881-1644)
- Yusuke Endo (ORCID: https://orcid.org/0000-0002-9637-1951)
Institutions
- Sapporo Medical University (JP)
- Jichi Medical University (JP)
- St. Marianna University School of Medicine (JP)
- Osaka Women's and Children's Hospital (JP)
- National Cerebral and Cardiovascular Center (JP)
- Juntendo University Urayasu Hospital (JP)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Rakuno Gakuen University (JP)
- Takenaka (Japan) (JP)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s40635-025-00821-0
- Citations
- 1
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Japan Society for the Promotion of Science