Iatrogenic neonatal hyperphosphatemia due to phosphate-containing enema

Irritability and ECG anomalies can be the only signs and symptoms of severe acute hyperphosphatemia after administration of PCE. Clinicians should be aware of the risk of severe acute hyperphosphatemia after PCE administration in infants, even without comorbidities, due to a low PTH status. When symptomatic hypocalcemia occurs, intravenous calcium administration is warranted, as the risk of life-threatening consequences from hypocalcemia significantly outweighs the risk of developing metastatic calcifications.

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Publication Details

Journal
Endocrinology Diabetes and Metabolism Case Reports
Published
2025-10-01
DOI
https://doi.org/10.1530/edm-25-0032
Citations
1
Primary Topic
Parathyroid Disorders and Treatments
Type
article
Field-Weighted Citation Impact
1.43
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article

Iatrogenic neonatal hyperphosphatemia due to phosphate-containing enema

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Endocrinology Diabetes and Metabolism Case Reports
Parathyroid Disorders and Treatments
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article

Iatrogenic neonatal hyperphosphatemia due to phosphate-containing enema

Willem Staels, Reiner Mauel, Elise Nauwynck, Jean De Schepper, Jesse Vanbesien, Koen Huysentruyt, Inge Gies, Céline De Cuyper
article en
1 citations

Abstract

Irritability and ECG anomalies can be the only signs and symptoms of severe acute hyperphosphatemia after administration of PCE. Clinicians should be aware of the risk of severe acute hyperphosphatemia after PCE administration in infants, even without comorbidities, due to a low PTH status. When symptomatic hypocalcemia occurs, intravenous calcium administration is warranted, as the risk of life-threatening consequences from hypocalcemia significantly outweighs the risk of developing metastatic calcifications.

Endocrinology Diabetes and Metabolism Case ReportsVol. 2025(4)
Vrije Universiteit Brussel (BE), Universitair Ziekenhuis Brussel (BE)
Openalex Percentile: Top 15%
Parathyroid Disorders and Treatments
1.43
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Iatrogenic neonatal hyperphosphatemia due to phosphate-containing enema — Willem Staels, Reiner Mauel, et al. · Endocrinology Diabetes and Metabolism Case Reports (2025) | TGRS Research Map | TGRS