Comparison of biological properties of human adipose tissue-derived mesenchymal stem/ stromal cells from healthy and diabetic donors: consequences for cell-based medicinal product development

The present study provides evidence of the biological potential of AT-MSCs from diabetic donors, which can be used as an active substance in the development of cell-based autologous advanced therapy medicinal products (ATMPs) dedicated for the treatment of e.g. osteoarthritis or myocardial infarction. Diabetic AT-MSCs in the used culture conditions are functional cells with greater chondrogenic and pro-angiogenic potential when compared to AT-MSCs from healthy donors. This increases the possibility of treating diabetic patients using their own cells.