S-adenosylmethionine enhances anti-PD-1 efficacy in uveal melanoma by targeting EZH2

As a potential anticancer drug, SAM can not only significantly inhibit the proliferation and migration of UM cells, but also promote apoptosis. In particular, SAM showed a stronger antitumor effect when it was combined with Pembrolizumab, providing a theoretical basis for the development of new strategies based on EZH2-targeted therapy and suggesting the potential of this combination therapy in clinical application.