Dietary iron attenuates epigenetic aging through DNA methylation remodeling and extends survival in older adults
This study establishes dietary iron as a modifiable determinant of epigenetic aging and mortality risk in older adults, with epigenetic recalibration mediating a substantial proportion of iron's protective effects. These findings suggest optimizing iron intake may represent a promising nutritional strategy to promote healthy aging.
Authors
- Huilin Yu (ORCID: https://orcid.org/0000-0003-3606-1449)
- Jiajun Zhao (ORCID: https://orcid.org/0000-0001-6224-1908)
- Qiufen Mo (ORCID: https://orcid.org/0000-0002-4892-1701)
- Siying Li (ORCID: https://orcid.org/0009-0002-1105-9262)
- Jianghua Zhang (ORCID: https://orcid.org/0000-0002-0783-6850)
- Qianqian Wang (ORCID: https://orcid.org/0009-0004-9065-555X)
Institutions
- Central South University of Forestry and Technology (CN)
- Zhejiang A & F University (CN)
- Central South University (CN)
- Donghua University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s13148-025-01986-x
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00