Immune, blood-brain barrier, and metabolic biomarkers mediate gut-brain axis crosstalk in alzheimer’s disease
Our study reveals a bidirectional gut-brain feedback loop in AD, in which gut microbiota promote neuroinflammation and immune aging, while AD exacerbates gut dysbiosis via lipid metabolic dysregulation. This self-reinforcing mechanism involving immune signaling, BBB disruption, and SCFA imbalance offers potential targets for integrated microbiota-based interventions in AD prevention.
Authors
- Zhenqiu Liu (ORCID: https://orcid.org/0000-0002-5244-6894)
- Mei Cui (ORCID: https://orcid.org/0000-0002-6449-8106)
- Xingdong Chen (ORCID: https://orcid.org/0000-0003-3763-160X)
- Yanfeng Jiang (ORCID: https://orcid.org/0000-0002-5006-5190)
- Chen Suo (ORCID: https://orcid.org/0000-0002-5274-4584)
- Yingzhe Wang (ORCID: https://orcid.org/0000-0002-7382-9683)
- Ding Ding (ORCID: https://orcid.org/0000-0001-9850-9224)
- Jin Li (ORCID: https://orcid.org/0000-0001-9201-2321)
- Jincheng Li (ORCID: https://orcid.org/0000-0002-8363-3916)
- Ziyu Yuan (ORCID: https://orcid.org/0000-0003-1434-0383)
- Jialin Li (ORCID: https://orcid.org/0000-0002-8541-2797)
Institutions
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
- Ministry of Education (KR)
- Huashan Hospital (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s40364-025-00851-6
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China