Pathology-interpretable radiomic model for predicting clinical outcome in patients with osteosarcoma: a retrospective, multicenter study
The MRI-based radiomic model shows potential in predicting DFS in osteosarcoma patients. Most radiomic features show only moderate associations with H&E-derived nuclear morphological features; they exhibit higher correlations with immune-related biomarkers.
Authors
- Shuixing Zhang (ORCID: https://orcid.org/0000-0001-7377-382X)
- Heng Zhao (ORCID: https://orcid.org/0000-0001-6549-4644)
- Yubin Yao (ORCID: https://orcid.org/0000-0002-9287-6354)
- Rongfang He
- Qiuping Ren
- Yinping Leng
- Nana Pei
- Yumeng Liu (ORCID: https://orcid.org/0000-0002-5055-2861)
- Xiaodong Zhang (ORCID: https://orcid.org/0000-0003-2217-6173)
- Yongxin Zhang (ORCID: https://orcid.org/0000-0001-9241-8743)
- Xia Xie (ORCID: https://orcid.org/0009-0001-3996-2456)
- Xiao Zhang (ORCID: https://orcid.org/0000-0002-2932-5875)
- Wenwen Liu (ORCID: https://orcid.org/0000-0001-7770-2658)
- Bin Zhang (ORCID: https://orcid.org/0000-0002-6286-6227)
- Ge Wen (ORCID: https://orcid.org/0000-0002-4805-8952)
- Na Tang (ORCID: https://orcid.org/0000-0001-6304-253X)
- Xiaoyang Zhang (ORCID: https://orcid.org/0009-0006-7836-1465)
- Jijie Xiao
- Xuewei Wu (ORCID: https://orcid.org/0000-0003-0447-0221)
Institutions
- Hebei Medical University (CN)
- Nanchang University (CN)
- Jinan University (CN)
- Hunan University of Science and Engineering (CN)
- Southern University of Science and Technology (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Nanfang Hospital (CN)
- Zhongshan People's Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Xiangyang Central Hospital (CN)
- Shantou Central Hospital (CN)
- First Affiliated Hospital of University of South China (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
- First Affiliated Hospital of Jinan University (CN)
- Southern Medical University (CN)
- University of South China (CN)
- Northeastern University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s12916-025-04424-0
- Citations
- 1
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Natural Science Foundation of China
- Jinan University
- China Scholarship Council
- National Key Research and Development Program of China