Inositol supplementation efficacy in improving key cardiometabolic and anthropometric indices: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials
Overall, inositol may offer modest cardiometabolic benefits, with moderate-to-high certainty for improvements in insulin resistance and lipid profiles. However, existing studies show a high risk of bias and low certainty of evidence, particularly for anthropometric outcomes, creating cautious interpretation. Future research should involve large-scale, rigorous trials with standardized protocols, longer follow-up, and diverse populations.
Authors
- Mouloud Agajani Delavar (ORCID: https://orcid.org/0000-0001-6906-1440)
- Niloufar Ahmadi (ORCID: https://orcid.org/0000-0003-4971-2351)
- Zeinab Ghorbani (ORCID: https://orcid.org/0000-0003-4230-5710)
- Sara K. Rosenkranz (ORCID: https://orcid.org/0000-0002-3297-1640)
- Parvaneh Mirabi (ORCID: https://orcid.org/0000-0002-8077-3569)
- Fatemeh Alibabaei-Omran
Institutions
- University of Nevada, Las Vegas (US)
- Guilan University of Medical Sciences (IR)
- Babol University of Medical Sciences (IR)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s13098-025-01980-6
- Primary Topic
- Phytase and its Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00