TRIM32 promotes tumor immune evasion and impedes Anti–PD-1 treatment by inducing immunosuppressive macrophages in gastric cancer
TRIM32/PDE9A axis promotes immune evasion in tumors and hinders the effectiveness of anti-PD-1 treatment by inducing TAMs recruitment and M2-like polarization in GC. This research provides insight into the role of TRIM32 in modulating tumor immunity and suggests that TRIM32 could be a promising target to overcoming resistance to anti-PD-1 therapy in GC.
Authors
- Jiapeng Xu
- Jun Wang (ORCID: https://orcid.org/0000-0001-9957-9208)
- Changming Wang (ORCID: https://orcid.org/0000-0002-3695-4311)
- Xujun Zhu
- Jian Xu (ORCID: https://orcid.org/0000-0003-2032-251X)
- Pengcheng Xiang (ORCID: https://orcid.org/0000-0003-3592-0002)
- Qingping Cai (ORCID: https://orcid.org/0000-0003-2383-4844)
- Zhiqing Hu (ORCID: https://orcid.org/0000-0002-3334-2002)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai East Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s12967-025-06330-8
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80