CircSipa1l1 modulates melanoma cell differentiation by activating the IGF2BP1-ARHGDIB axis and ERK signaling pathway
Our findings reveal that circSipa1l1 acts as an oncogenic circRNA by regulating the IGF2BP1/ARHGDIB/ERK axis in melanoma, suggesting it could be a potential therapeutic target for melanoma differentiation therapy.
Authors
- Dan Shi (ORCID: https://orcid.org/0000-0002-8585-1669)
- Tao Meng (ORCID: https://orcid.org/0000-0002-7390-3601)
- Bo-han Li
- Jixian Zhai (ORCID: https://orcid.org/0000-0002-0217-0666)
- Tianyue An (ORCID: https://orcid.org/0000-0002-7291-3752)
- Sixue Bi
- Xiaojuan He (ORCID: https://orcid.org/0000-0003-0553-0919)
- Defang Li (ORCID: https://orcid.org/0000-0003-4151-9151)
- Ling Liu
- Guoli Wang (ORCID: https://orcid.org/0000-0001-7390-3188)
- Jun Lü (ORCID: https://orcid.org/0000-0002-9361-6087)
- Qiusheng Zheng (ORCID: https://orcid.org/0000-0001-6413-9878)
- Xueli Wang (ORCID: https://orcid.org/0000-0002-8382-9425)
- Qingling Jiang (ORCID: https://orcid.org/0000-0002-6286-6614)
- Zegang Pan
- Xiaoman Xu
Institutions
- Shihezi University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Southwest Medical University (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- China Academy of Chinese Medical Sciences (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s12967-025-07233-4
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00