Seasonal PM2.5 exposures induce differential responses to influenza A virus infection in primary human airway epithelial cells
Seasonal variations in PM2.5 composition during winter, spring, and fall-coinciding with influenza season-likely enhance pro-inflammatory responses to viral infection, with early inflammation contributing to worsened pathogenesis.
Authors
- Timothy Smyth (ORCID: https://orcid.org/0000-0001-8837-8021)
- Joseph Patrick Pancras
- Stephanie A. Brocke (ORCID: https://orcid.org/0000-0002-1916-799X)
- Hong Dang (ORCID: https://orcid.org/0000-0002-7305-4208)
- Ilona Jaspers (ORCID: https://orcid.org/0000-0001-8728-0305)
- C. B. Christianson
- Michael D. Hays (ORCID: https://orcid.org/0000-0002-4029-8660)
- Weidong Wu (ORCID: https://orcid.org/0000-0002-7334-8679)
- Adam M. Speen (ORCID: https://orcid.org/0000-0002-3153-8378)
- Kasey Kovalcik (ORCID: https://orcid.org/0000-0003-0917-5459)
- Yong Ho Kim (ORCID: https://orcid.org/0000-0001-7527-0134)
- Zhen An (ORCID: https://orcid.org/0000-0002-1651-0924)
Institutions
- University of North Carolina at Chapel Hill (US)
- Environmental Protection Agency (US)
- Research Triangle Park Foundation (US)
- Lung Institute (US)
- Henan Medical University (CN)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s12989-025-00643-8
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Environmental Protection Agency
- National Heart, Lung, and Blood Institute
- National Institute of Environmental Health Sciences