Microgravity-driven Rab27B activation amplifies mesenchymal stem cell-derived extracellular vesicle production and functions
This study identifies microgravity as an effective platform for the large-scale production of high-quality UCMSC-EVs, addressing key manufacturing barriers and accelerating the clinical translation of EVs-based therapies.
Authors
- Yiru Fu
- Yi� Ding (ORCID: https://orcid.org/0000-0001-5035-9255)
- Meng Sun (ORCID: https://orcid.org/0000-0002-8188-9264)
- An‐Ping Li (ORCID: https://orcid.org/0000-0003-4400-7493)
- Ye Li (ORCID: https://orcid.org/0000-0002-1624-8831)
- Yue Li (ORCID: https://orcid.org/0000-0001-9730-477X)
Institutions
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s13287-025-04711-w
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Wuhan University