eNAMPT/TLR4 signaling drives PAH cellular phenotypic switching and lung vascular remodeling
Autocrine/paracrine eNAMPT/TLR4 signaling contributes to accelerated cellular phenotypic switching, a druggable strategy to reverse vascular remodeling.
Authors
- Nancy G. Casanova (ORCID: https://orcid.org/0000-0002-6363-2414)
- Zhiyu Dai (ORCID: https://orcid.org/0000-0002-2945-7923)
- Carrie L. Kempf
- Panayiotis V. Benos (ORCID: https://orcid.org/0000-0003-3172-3132)
- Jin H. Song (ORCID: https://orcid.org/0000-0002-0123-2909)
- Sara M. Camp
- Joe G. N. Garcia (ORCID: https://orcid.org/0000-0002-6934-0420)
- Andrew J. Bryant (ORCID: https://orcid.org/0000-0001-9433-3049)
- Ayako Makino (ORCID: https://orcid.org/0000-0003-1259-8604)
- Shaira Limson Kee (ORCID: https://orcid.org/0000-0002-4330-4595)
- Nahla Zaghloul (ORCID: https://orcid.org/0000-0001-7172-7395)
- Ankit A. Desai (ORCID: https://orcid.org/0000-0001-6427-616X)
- Saad Sammani (ORCID: https://orcid.org/0000-0002-7933-6388)
- Akash Gupta (ORCID: https://orcid.org/0000-0001-7305-055X)
- Mohamed Ahmed
- Jason X.‐J. Yuan
- Aikseng Ooi
- Marisela Rodriguez
Institutions
- Scripps Research Institute (US)
- University of Arizona (US)
- Washington University in St. Louis (US)
- University of Florida Health (US)
- University of Florida (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Florida Health Science Center (US)
- Florida College (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s12964-025-02421-7
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health