Trifluoromethyl–pyrazole–carboxamides as COX inhibitors: synthesis, microed structural analysis, computational profiling, and biological evaluation
Compounds 3b, 3d, and 3g demonstrated potent COX inhibition with notable COX-2 selectivity, supporting their promise as leads for safer anti-inflammatory drug development. Additionally, compound 3a displayed moderate cytotoxic effects against several cancer cell lines, suggesting possible dual anti-inflammatory and anticancer potential. Overall, the favorable drug-like properties and low toxicity profiles justify further preclinical investigation of these pyrazole-carboxamide derivatives.
Authors
- P.M. Dominiak (ORCID: https://orcid.org/0000-0002-1466-1243)
- Mohammed Hawash (ORCID: https://orcid.org/0000-0001-5640-9700)
- Mohammed T. Qaoud (ORCID: https://orcid.org/0000-0002-9563-9493)
- Murad Abualhasan (ORCID: https://orcid.org/0000-0002-2083-856X)
- Barbara Olech (ORCID: https://orcid.org/0000-0002-8524-5300)
- İrfan Çapan (ORCID: https://orcid.org/0000-0002-9555-1555)
- Anil Kumar (ORCID: https://orcid.org/0009-0005-8471-2690)
- Nisreen Shweiki
Institutions
- Cyprus International University (CY)
- An-Najah National University (PS)
- Software Research and Development Consulting (TR)
- University of Warsaw (PL)
- Gazi University (TR)
Publication Details
- Journal
- BMC Chemistry
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s13065-025-01659-z
- Citations
- 1
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- An-Najah National University
- Gazi Üniversitesi
- Uniwersytet Warszawski