The role of an anti-inflammatory molecule AIM/CD5L in gut ischemia/reperfusion injury of male mice
In male mice, gut I/R decreases AIM protein levels and mRNA expression in the lungs as well as AIM plasma concentration. AIM reduces eCIRP-induced pro-inflammatory cytokine production in macrophages, potentially by inhibiting eCIRP's binding to TLR4 and TREM-1. These findings suggest AIM is a promising therapeutic candidate in males with gut I/R.
Authors
- Alok Jha (ORCID: https://orcid.org/0000-0002-2514-9210)
- Monowar Aziz
- Russell Hollis (ORCID: https://orcid.org/0000-0003-0143-3337)
- Megan Tenet (ORCID: https://orcid.org/0000-0001-8620-0609)
- Takayuki Kato (ORCID: https://orcid.org/0000-0001-8839-9594)
- Gaifeng Ma
- Ping Wang (ORCID: https://orcid.org/0000-0002-1557-0394)
Institutions
- Northwell Health (US)
- Feinstein Institute for Medical Research (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1186/s10020-025-01385-1
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health