Primary epithelioid angiomatous nodule of the vocal cord: A case report and literature review

A primary epithelioid angiomatous nodule (EAN) of the vocal cord is a rare vascular endothelial cell-derived lesion. The present study describes the clinical, histopathological and immunohistochemical characteristics of a 31-year-old male patient with EAN of the vocal cord and reviews the relevant literature. The patient complained of recurrent hoarseness for over a month. A fiber laryngoscopy revealed a red polypoid mass on the left vocal cord. Post-surgical resection, the microscopic examination revealed clear tumor boundaries, a solid arrangement of epithelioid tumor cells, obvious nucleoli, vacuolated nuclei, eosinophilic or clear cytoplasm, no mitotic figures and scant inflammatory cell infiltration. The immunohistochemical results also showed positivity for CD34 and CD31 in the tumor cells. Fluorescence <i>in situ</i> hybridization excluded calmodulin-binding transcription activator 1 rearrangement. The patient was followed up for 6 months and no recurrence was found. However, close follow-up is necessary in this case due to a positive surgical margin.