CKAP4 Promotes Atrial Fibrosis and Enhances Atrial Fibrillation Vulnerability via WNT/β-Catenin Activation

CKAP4 promotes atrial fibrosis and increases AF vulnerability through the WNT/β-catenin signaling pathway, highlighting the CKAP4-WNT/β-catenin axis as a promising therapeutic target to attenuate atrial structural remodeling in AF.

Authors

Yuntao Feng (ORCID: https://orcid.org/0000-0001-8224-7063)
Zhisong Chen (ORCID: https://orcid.org/0000-0002-1525-4236)
Hongwei Tan (ORCID: https://orcid.org/0000-0001-6542-7927)
Xuebo Liu (ORCID: https://orcid.org/0000-0001-9985-8960)
Yanhua Gao

Institutions

Tongji University (CN)
Shanghai Pulmonary Hospital (CN)
Tongji Hospital (CN)

Publication Details

Journal: Circulation Arrhythmia and Electrophysiology
Published: 2025-10-29
DOI: https://doi.org/10.1161/circep.125.014217
Primary Topic: Atrial Fibrillation Management and Outcomes
Type: article
Field-Weighted Citation Impact: 0.00

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article

CKAP4 Promotes Atrial Fibrosis and Enhances Atrial Fibrillation Vulnerability via WNT/β-Catenin Activation

Yuntao Feng, Zhisong Chen, Hongwei Tan, Xuebo Liu et al.

Oct 29, 2025

Circulation Arrhythmia and Electrophysiology

Atrial Fibrillation Management and Outcomes

article

CKAP4 Promotes Atrial Fibrosis and Enhances Atrial Fibrillation Vulnerability via WNT/β-Catenin Activation

Yuntao Feng, Zhisong Chen, Hongwei Tan, Xuebo Liu, Yanhua Gao

October 29, 2025article en

Abstract

CKAP4 promotes atrial fibrosis and increases AF vulnerability through the WNT/β-catenin signaling pathway, highlighting the CKAP4-WNT/β-catenin axis as a promising therapeutic target to attenuate atrial structural remodeling in AF.

Circulation Arrhythmia and ElectrophysiologyVol. 18(11)

Tongji University (CN), Shanghai Pulmonary Hospital (CN), Tongji Hospital (CN)

Openalex Percentile: Top 53%

Atrial Fibrillation Management and Outcomes

DOI Open Access PDF OpenAlex

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